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Infection and Immunity, November 2003, p. 6607-6609, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6607-6609.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Role of Actin Filament Network in Burkholderia multivorans Invasion in Well-Differentiated Human Airway Epithelia

Ute E. Schwab,1* Carla M. P. Ribeiro,1 Heiner Neubauer,2 and Richard C. Boucher1

Cystic Fibrosis/Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7248,1 FAF Medical Academy, Institute of Microbiology, Munich, Germany2

Received 8 May 2003/ Returned for modification 12 June 2003/ Accepted 13 August 2003

The role of the actin-based cytoskeleton in the internalization process of Burkholderia multivorans by well-differentiated human airway epithelia was investigated by immunohistology and confocal microscopy. Our data suggest that an intact actin cytoskeleton is required for biofilm formation but not single cell entry or paracytosis.

* Corresponding author. Present address: 415 Stocking Hall, Cornell University, Ithaca, NY 14853. Phone: (607) 254-4967. Fax: (607) 254-4868. E-mail: ues3{at}cornell.edu.

Editor: D. L. Burns

Infection and Immunity, November 2003, p. 6607-6609, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6607-6609.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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  • McClean, S., Callaghan, M. (2009). Burkholderia cepacia complex: epithelial cell-pathogen confrontations and potential for therapeutic intervention. J Med Microbiol 58: 1-12 [Abstract] [Full Text]  
  • Kim, J. Y., Sajjan, U. S., Krasan, G. P., LiPuma, J. J. (2005). Disruption of Tight Junctions during Traversal of the Respiratory Epithelium by Burkholderia cenocepacia. Infect. Immun. 73: 7107-7112 [Abstract] [Full Text]  


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