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Infection and Immunity, November 2003, p. 6615-6619, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6615-6619.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Vaccination with Toxoplasma gondii SAG-1 Protein Is Protective against Congenital Toxoplasmosis in BALB/c Mice but Not in CBA/J Mice

Valerie Letscher-Bru,1* Alexander W. Pfaff,1 Ahmed Abou-Bacar,1 Denis Filisetti,1 Elisabeth Antoni,1 Odile Villard,1 Jean-Paul Klein,2 and Ermanno Candolfi1

Institut de Parasitologie et de Pathologie Tropicale, INSERM U 392, Faculté de Médecine,1 Faculté de Pharmacie, Université de Strasbourg, 67000 Strasbourg, France2

Received 14 April 2003/ Returned for modification 20 May 2003/ Accepted 4 August 2003

We evaluated the effect of vaccination with the SAG1 protein of Toxoplasma gondii against congenital toxoplasmosis in mice with different genetic backgrounds. In BALB/c mice (H-2d), vaccination reduced the number of infected fetuses by 50% and was associated with a mixed type 1 and type 2 immunity. In CBA/J mice (H-2k), vaccination increased the number of infected fetuses by 50% and was associated with a predominant type 2 response. Our results indicate that the effect of vaccination with SAG1 is controlled by the genetic background of the mouse.

* Corresponding author. Mailing address: Institut de Parasitologie et de Pathologie Tropicale, Faculté de Médecine, Université de Strasbourg, 3 rue Koeberlé, 67000 Strasbourg, France. Phone: 33 3 90 24 37 00. Fax: 33 3 90 24 36 93. E-mail: valerie.letscher{at}medecine.u-strasbg.fr.

Infection and Immunity, November 2003, p. 6615-6619, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6615-6619.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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