This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Duffy, P. E.
Right arrow Articles by Fried, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Duffy, P. E.
Right arrow Articles by Fried, M.

 Previous Article  |  Next Article 

Infection and Immunity, November 2003, p. 6620-6623, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6620-6623.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Antibodies That Inhibit Plasmodium falciparum Adhesion to Chondroitin Sulfate A Are Associated with Increased Birth Weight and the Gestational Age of Newborns

Patrick E. Duffy1,2* and Michal Fried1

Malaria Antigen Discovery Program, Seattle Biomedical Research Institute, Seattle, Washington 98109,1 Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, Maryland 209102

Received 3 March 2003/ Returned for modification 2 June 2003/ Accepted 8 August 2003

Antibodies that inhibit Plasmodium falciparum adhesion to the placental receptor chondroitin sulfate A are associated with a reduced risk of placental malaria, but whether these antibodies lead to improved pregnancy outcomes is unknown. We measured antiadhesion antibody levels in parturient women in western Kenya, where malaria transmission is intense. Secundigravid women with antiadhesion activity in their plasma delivered babies that were on average 398 g heavier (P = 0.019) and 2 weeks more mature (P = 0.002) than babies delivered to secundigravidas without antiadhesion activity. Our findings support the development of antiadhesion vaccines to prevent poor fetal outcomes due to pregnancy malaria.

* Corresponding author. Mailing address: Malaria Antigen Discovery Program, 4 Nickerson St., Suite 200, Seattle, WA 98109. Phone: (206) 284-8846, ext. 311. Fax: (206) 284-0313. E-mail: patrick.duffy{at}sbri.org.

Editor: J. M. Mansfield

Infection and Immunity, November 2003, p. 6620-6623, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6620-6623.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Nielsen, M. A., Pinto, V. V., Resende, M., Dahlback, M., Ditlev, S. B., Theander, T. G., Salanti, A. (2009). Induction of Adhesion-Inhibitory Antibodies against Placental Plasmodium falciparum Parasites by Using Single Domains of VAR2CSA. Infect. Immun. 77: 2482-2487 [Abstract] [Full Text]  
  • Jaworowski, A., Fernandes, L. A., Yosaatmadja, F., Feng, G., Mwapasa, V., Molyneux, M. E., Meshnick, S. R., Lewis, J., Rogerson, S. J. (2009). Relationship between Human Immunodeficiency Virus Type 1 Coinfection, Anemia, and Levels and Function of Antibodies to Variant Surface Antigens in Pregnancy-Associated Malaria. CVI 16: 312-319 [Abstract] [Full Text]  
  • Vestergaard, L. S., Lusingu, J. P., Nielsen, M. A., Mmbando, B. P., Dodoo, D., Akanmori, B. D., Alifrangis, M., Bygbjerg, I. C., Lemnge, M. M., Staalsoe, T., Hviid, L., Theander, T. G. (2008). Differences in Human Antibody Reactivity to Plasmodium falciparum Variant Surface Antigens Are Dependent on Age and Malaria Transmission Intensity in Northeastern Tanzania. Infect. Immun. 76: 2706-2714 [Abstract] [Full Text]  
  • Dembo, E. G., Mwapasa, V., Montgomery, J., Craig, A. G., Porter, K. A., Meshnick, S. R., Molyneux, M. E., Rogerson, S. J. (2008). Impact of Human Immunodeficiency Virus Infection in Pregnant Women on Variant-Specific Immunity to Malaria. CVI 15: 617-621 [Abstract] [Full Text]  
  • Avril, M., Kulasekara, B. R., Gose, S. O., Rowe, C., Dahlback, M., Duffy, P. E., Fried, M., Salanti, A., Misher, L., Narum, D. L., Smith, J. D. (2008). Evidence for Globally Shared, Cross-Reacting Polymorphic Epitopes in the Pregnancy-Associated Malaria Vaccine Candidate VAR2CSA. Infect. Immun. 76: 1791-1800 [Abstract] [Full Text]  
  • Rogerson, S. J., Mwapasa, V., Meshnick, S. R. (2007). Malaria in Pregnancy: Linking Immunity and Pathogenesis to Prevention. Am J Trop Med Hyg 77: 14-22 [Abstract] [Full Text]  
  • Kyes, S. A., Kraemer, S. M., Smith, J. D. (2007). Antigenic Variation in Plasmodium falciparum: Gene Organization and Regulation of the var Multigene Family. Eukaryot Cell 6: 1511-1520 [Full Text]  
  • Beeson, J. G., Ndungu, F., Persson, K. E. M., Chesson, J. M., Kelly, G. L., Uyoga, S., Hallamore, S. L., Williams, T. N., Reeder, J. C., Brown, G. V., Marsh, K. (2007). Antibodies among Men and Children to Placental-Binding Plasmodium falciparum-Infected Erythrocytes that Express var2csa. Am J Trop Med Hyg 77: 22-28 [Abstract] [Full Text]  
  • Muehlenbachs, A., Fried, M., Lachowitzer, J., Mutabingwa, T. K., Duffy, P. E. (2007). Genome-Wide Expression Analysis of Placental Malaria Reveals Features of Lymphoid Neogenesis during Chronic Infection. J. Immunol. 179: 557-565 [Abstract] [Full Text]  
  • Hviid, L. (2007). Adhesion Specificities of Plasmodium falciparum-Infected Erythrocytes Involved in the Pathogenesis of Pregnancy-Associated Malaria. Am. J. Pathol. 170: 1817-1819 [Full Text]  
  • Bir, N., Yazdani, S. S., Avril, M., Layez, C., Gysin, J., Chitnis, C. E. (2006). Immunogenicity of Duffy Binding-Like Domains That Bind Chondroitin Sulfate A and Protection against Pregnancy-Associated Malaria.. Infect. Immun. 74: 5955-5963 [Abstract] [Full Text]  
  • BENET, A., KHONG, T. Y., URA, A., SAMEN, R., LORRY, K., MELLOMBO, M., TAVUL, L., BAEA, K., ROGERSON, S. J., CORTES, A. (2006). PLACENTAL MALARIA IN WOMEN WITH SOUTH-EAST ASIAN OVALOCYTOSIS.. Am J Trop Med Hyg 75: 597-604 [Abstract] [Full Text]  
  • Rasti, N., Namusoke, F., Chene, A., Chen, Q., Staalsoe, T., Klinkert, M.-Q., Mirembe, F., Kironde, F., Wahlgren, M. (2006). Nonimmune immunoglobulin binding and multiple adhesion characterize Plasmodium falciparum-infected erythrocytes of placental origin. Proc. Natl. Acad. Sci. USA 103: 13795-13800 [Abstract] [Full Text]  
  • Duffy, M. F., Caragounis, A., Noviyanti, R., Kyriacou, H. M., Choong, E. K., Boysen, K., Healer, J., Rowe, J. A., Molyneux, M. E., Brown, G. V., Rogerson, S. J. (2006). Transcribed var Genes Associated with Placental Malaria in Malawian Women.. Infect. Immun. 74: 4875-4883 [Abstract] [Full Text]  
  • Haase, R. N., Megnekou, R., Lundquist, M., Ofori, M. F., Hviid, L., Staalsoe, T. (2006). Plasmodium falciparum Parasites Expressing Pregnancy-Specific Variant Surface Antigens Adhere Strongly to the Choriocarcinoma Cell Line BeWo.. Infect. Immun. 74: 3035-3038 [Abstract] [Full Text]  
  • Elliott, S. R., Brennan, A. K., Beeson, J. G., Tadesse, E., Molyneux, M. E., Brown, G. V., Rogerson, S. J. (2005). Placental Malaria Induces Variant-Specific Antibodies of the Cytophilic Subtypes Immunoglobulin G1 (IgG1) and IgG3 That Correlate with Adhesion Inhibitory Activity. Infect. Immun. 73: 5903-5907 [Abstract] [Full Text]  
  • Megnekou, R., Staalsoe, T., Taylor, D. W, Leke, R., Hviid, L. (2005). Effects of Pregnancy and Intensity of Plasmodium falciparum Transmission on Immunoglobulin G Subclass Responses to Variant Surface Antigens. Infect. Immun. 73: 4112-4118 [Abstract] [Full Text]  
  • Elliott, S. R., Duffy, M. F., Byrne, T. J., Beeson, J. G., Mann, E. J., Wilson, D. W., Rogerson, S. J., Brown, G. V. (2005). Cross-Reactive Surface Epitopes on Chondroitin Sulfate A-Adherent Plasmodium falciparum-Infected Erythrocytes Are Associated with Transcription of var2csa. Infect. Immun. 73: 2848-2856 [Abstract] [Full Text]  
  • Smith, J. D., Deitsch, K. W. (2004). Pregnancy-associated Malaria and the Prospects for Syndrome-specific Antimalaria Vaccines. JEM 200: 1093-1097 [Abstract] [Full Text]  
  • Salanti, A., Dahlback, M., Turner, L., Nielsen, M. A., Barfod, L., Magistrado, P., Jensen, A. T.R., Lavstsen, T., Ofori, M. F., Marsh, K., Hviid, L., Theander, T. G. (2004). Evidence for the Involvement of VAR2CSA in Pregnancy-associated Malaria. JEM 200: 1197-1203 [Abstract] [Full Text]  
  • Staalsoe, T., Shulman, C. E, Dorman, E. K., Kawuondo, K., Marsh, K., Hviid, L. (2004). Intermittent Preventive Sulfadoxine-Pyrimethamine Treatment of Primigravidae Reduces Levels of Plasma Immunoglobulin G, Which Protects against Pregnancy-Associated Plasmodium falciparum Malaria. Infect. Immun. 72: 5027-5030 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»