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Infection and Immunity, November 2003, p. 6648-6652, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6648-6652.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Novel Role for Albumin in Innate Immunity: Serum Albumin Inhibits the Growth of Blastomyces dermatitidis Yeast Form In Vitro

Steven Giles and Charles Czuprynski*

Department of Pathobiological Sciences, School of Veterinary Medicine, Madison, Wisconsin 53706

Received 23 June 2003/ Returned for modification 9 July 2003/ Accepted 11 August 2003

In this study we found that serum inhibitory activity against Blastomyces dermatitidis was principally mediated by albumin. This was confirmed in experiments using albumin from several mammalian species. Analbuminemic rat serum did not inhibit B. dermatitidis growth in vivo; however, the addition of albumin restored inhibitory activity. Inhibitory activity does not require albumin domain III and appears to involve binding of a low-molecular-weight yeast-derived growth factor.

* Corresponding author. Mailing address: University of Wisconsin—Madison, School of Veterinary Medicine, 2015 Linden Dr., West Madison, WI 53706. Phone: (608) 262-8102. Fax: (608) 262-8102. E-mail: CZUPRYNC{at}SVM.VETMED.WISC.EDU.

Editor: T. R. Kozel

Infection and Immunity, November 2003, p. 6648-6652, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6648-6652.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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