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Infection and Immunity, November 2003, p. 6658-6663, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6658-6663.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Differences in Host Susceptibility to Disease Progression in the Human Challenge Model of Haemophilus ducreyi Infection

Stanley M. Spinola,1,2,3* Cliffton T. H. Bong,1,{dagger} Andrew L. Faber,2 Kate R. Fortney,1 Stacy L. Bennett,1 Carisa A. Townsend,1 Beth E. Zwickl,1 Steven D. Billings,3,4 Tricia L. Humphreys,1 Margaret E. Bauer,1 and Barry P. Katz1

Departments of Medicine,1 Microbiology and Immunology,2 Pathology and Laboratory Medicine,3 Dermatology, School of Medicine, Indiana University, Indianapolis, Indiana 462024

Received 16 June 2003/ Returned for modification 21 July 2003/ Accepted 7 August 2003

With human volunteers inoculated at two sites with Haemophilus ducreyi, outcomes for a subject were not independent. In a reinfection trial, 2 of 11 previous pustule formers and 6 of 10 previous resolvers resolved all sites of infection. There was no correlation between serum bactericidal or phagocytic activity and outcome in the trial. These data indicate that different hosts are differentially susceptible to disease progression versus resolution in the model.

* Corresponding author. Mailing address: Department of Medicine, Indiana University, 435 Emerson Hall, 545 Barnhill Dr., Indianapolis, IN 46202-5124. Phone: (317) 274-1427. Fax: (317) 274-1587. E-mail: sspinola{at}iupui.edu.

{dagger} Present address: Department of Medicine, UCLA Geffen School of Medicine, Westwood, Calif.

Infection and Immunity, November 2003, p. 6658-6663, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6658-6663.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Bauer, M. E., Fortney, K. R., Harrison, A., Janowicz, D. M., Munson, R. S., Spinola, S. M. (2008). Identification of Haemophilus ducreyi genes expressed during human infection. Microbiology 154: 1152-1160 [Abstract] [Full Text]  
  • Humphreys, T. L., Li, L., Li, X., Janowicz, D. M., Fortney, K. R., Zhao, Q., Li, W., McClintick, J., Katz, B. P., Wilkes, D. S., Edenberg, H. J., Spinola, S. M. (2007). Dysregulated Immune Profiles for Skin and Dendritic Cells Are Associated with Increased Host Susceptibility to Haemophilus ducreyi Infection in Human Volunteers. Infect. Immun. 75: 5686-5697 [Abstract] [Full Text]  
  • Banks, K. E., Humphreys, T. L., Li, W., Katz, B. P., Wilkes, D. S., Spinola, S. M. (2007). Haemophilus ducreyi Partially Activates Human Myeloid Dendritic Cells. Infect. Immun. 75: 5678-5685 [Abstract] [Full Text]  
  • Janowicz, D., Leduc, I., Fortney, K. R., Katz, B. P., Elkins, C., Spinola, S. M. (2006). A DltA Mutant of Haemophilus ducreyi Is Partially Attenuated in Its Ability To Cause Pustules in Human Volunteers. Infect. Immun. 74: 1394-1397 [Abstract] [Full Text]  
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  • Janowicz, D. M., Fortney, K. R., Katz, B. P., Latimer, J. L., Deng, K., Hansen, E. J., Spinola, S. M. (2004). Expression of the LspA1 and LspA2 Proteins by Haemophilus ducreyi Is Required for Virulence in Human Volunteers. Infect. Immun. 72: 4528-4533 [Abstract] [Full Text]  
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