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Infection and Immunity, November 2003, p. 6664-6667, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6664-6667.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Helicobacter pylori cag Pathogenicity Island Is Associated with Reduced Expression of Interleukin-4 (IL-4) mRNA and Modulation of the IL-4{delta}2 mRNA Isoform in Human Gastric Mucosa

Barbara Orsini,1* Barbara Ottanelli,1 Amedeo Amedei,2 Elisabetta Surrenti,1 Marco Capanni,1 Gianfranco Del Prete,2 Andrea Amorosi,3 Stefano Milani,1 Mario Milco D'Elios,2 and Calogero Surrenti1

Gastroenterology Unit, Department of Clinical Pathophysiology,1 Department of Internal Medicine,2 Department of Pathology, University of Florence, Florence, Italy3

Received 21 April 2003/ Returned for modification 9 June 2003/ Accepted 23 July 2003

Interleukin-4 (IL-4) and IL-4{delta}2 mRNA gastric expression was evaluated in healthy subjects and patients who did not have ulcers but were infected with Helicobacter pylori with or without the cag pathogenicity island (cag PAI). IL-4 mRNA was physiologically expressed by gastric epithelium and negatively influenced by H. pylori. Also, nonepithelial cells in the lamina propria of H. pylori-infected patients expressed IL-4 mRNA, whereas IL-4{delta}2 mRNA was found only in cag PAI-negative patients. Thus, gastric IL-4 takes part in the local immune response to H. pylori.

* Corresponding author. Mailing address: Department of Clinical Pathophysiology, Gastroenterology Unit, CIRHeP, Viale Pieraccini 6, I-50139 Florence, Italy. Phone: 39-055-4271301. Fax: 39-055-4271297. E-mail: b.orsini{at}dfc.unifi.it.

Editor: J. D. Clements

Infection and Immunity, November 2003, p. 6664-6667, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6664-6667.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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