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Infection and Immunity, November 2003, p. 6672-6675, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6672-6675.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Legionella pneumophila Suppresses Macrophage Interleukin-12 Production by Activating the p42/44 Mitogen-Activated Protein Kinase Cascade

Kazuto Matsunaga, Hiroyuki Yamaguchi, Thomas W. Klein, Herman Friedman, and Yoshimasa Yamamoto*

Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida 33612

Received 21 January 2003/ Returned for modification 28 February 2003/ Accepted 6 August 2003

A possible involvement of the mitogen-activated protein (MAP) kinase cascade in the inhibition of macrophage interleukin-12 (IL-12) production by Legionella pneumophila infection was examined. The results of MAP kinase inhibition by p42/44 and p38 MAP kinase inhibitors and of p42/44 MAP kinase activity assays indicate that L. pneumophila infection of macrophages causes a selective inhibition of lipopolysaccharide-induced IL-12 production by activating the p42/44 MAP kinase cascade. In addition, it was also revealed that the p38 MAP kinase may be important for the production of IL-12 but not for the inhibition caused by L. pneumophila infection.

* Corresponding author. Present address: Division of Molecular Microbiology, Department of Basic Laboratory Sciences, School of Allied Health Sciences, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan. Phone: 81-6-6879-2580. Fax: 81-6-6879-2499. E-mail: yyamamot{at}sahs.med.osaka-u.ac.jp.

Editor: J. M. Mansfield

Infection and Immunity, November 2003, p. 6672-6675, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6672-6675.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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