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Infection and Immunity, November 2003, p. 6676-6679, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6676-6679.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae

Aras Kadioglu,1* Josè Echenique,2,{dagger} Sonia Manco,1 Marie-Claude Trombe,2 and Peter W. Andrew1

Department of Microbiology and Immunology, University of Leicester, Leicester LE1 9HN, United Kingdom,1 Université Paul Sabatier, Institut Fèdèratif de Recherche 31, 31403 Toulouse, France2

Received 16 April 2003/ Returned for modification 20 June 2003/ Accepted 29 July 2003

In Streptococcus pneumoniae, the two-component signaling system MicAB was previously shown to contribute to repression of competence when oxygen is limited. In virulent strains expressing the serotype 2 and 6 capsule, mutation of the MicB kinase reduced the lag period of growth when cultures were switched from an aerobic to anaerobic atmosphere. After intranasal challenge of mice, the micB::km mutation decreased virulence, as shown by the absence of symptoms and by a lower level of recovery of CFU from lungs and blood. It is proposed that MicAB is involved in the adaptive response of the bacteria to changes in oxygen level during the course of infection.

* Corresponding author. Present address: Department of Infection, Immunity, and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, United Kingdom. Phone: 0116 2523018. Fax: 0116 2525030. E-mail: ak13{at}le.ac.uk.

{dagger} Present address: Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Pabellon Argentina, Ciudad Universitaria, CP 5000 Cordoba, Argentina.

{ddagger} Present address: Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom.

Infection and Immunity, November 2003, p. 6676-6679, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6676-6679.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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