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Infection and Immunity, November 2003, p. 6680-6685, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6680-6685.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Secretion of the orgC Gene Product by Salmonella enterica Serovar Typhimurium

James B. Day* and Catherine A. Lee

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115

Received 31 March 2003/ Returned for modification 22 May 2003/ Accepted 7 August 2003

HilA activates the transcription of genes on Salmonella pathogenicity island 1 (SPI1), which encodes a type III secretion system (TTSS). Previous studies showed that transposon insertions in orgC, a gene located on SPI1, increase hilA expression. We characterize the orgC gene product and show that it is secreted via the SPI1 TTSS. We propose a model whereby OrgC functions as a secreted repressor of the SPI1 virulence genes.

* Corresponding author. Mailing address: Center for Food Safety and Applied Nutrition, Food and Drug Administration, HFS-300, 5100 Paint Branch Parkway, College Park, MD 20740. Phone: (301) 436-2013. Fax: (301) 436-2632. E-mail: james.day{at}cfsan.fda.gov.

Editor: B. B. Finlay

Infection and Immunity, November 2003, p. 6680-6685, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6680-6685.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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