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Infection and Immunity, November 2003, p. 6680-6685, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6680-6685.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Secretion of the orgC Gene Product by Salmonella enterica Serovar Typhimurium

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115

Received 31 March 2003/ Returned for modification 22 May 2003/ Accepted 7 August 2003

HilA activates the transcription of genes on Salmonella pathogenicity island 1 (SPI1), which encodes a type III secretion system (TTSS). Previous studies showed that transposon insertions in orgC, a gene located on SPI1, increase hilA expression. We characterize the orgC gene product and show that it is secreted via the SPI1 TTSS. We propose a model whereby OrgC functions as a secreted repressor of the SPI1 virulence genes.

Editor: B. B. Finlay

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