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Infection and Immunity, December 2003, p. 7159-7163, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7159-7163.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Interleukin-10 and Pathogenesis of Murine Ocular Toxoplasmosis

Fangli Lu,1,2,{dagger} Shiguang Huang,1,3,{ddagger} and Lloyd H. Kasper1*

Department of Medicine and Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756,1 Sun Yat-sen University School of Medicine, Guangzhou 510089,2 Jinan University School of Medicine, Guangzhou 510632, China3

Received 14 July 2003/ Returned for modification 10 August 2003/ Accepted 16 September 2003

To understand the role of interleukin-10 (IL-10) in ocular toxoplasmosis, we compared C57BL/6 (B6) and BALB/c background mice lacking a functional IL-10 gene (IL-10-/-) and B6 transgenic mice expressing IL-10 under the control of the IL-2 promoter. Increased cellular infiltration and necrosis were observed in the eye tissue of IL-10-/- mice of both the B6 and BALB/c backgrounds with associated changes in the levels of cytokines in serum. In contrast, there was no evidence of necrosis in the eye tissue from IL-10 transgenic mice following parasite exposure. Our results demonstrate that IL-10 is important in the regulation of inflammation during acute ocular toxoplasmosis.

* Corresponding author. Mailing address: Department of Medicine and Microbiology, Dartmouth Medical School, 640E Borwell, Lebanon, NH 03756. Phone: (603) 650-8787. Fax: (603) 650-8799. E-mail: Lloyd.H.Kasper{at}Dartmouth.edu.

Editor: W. A. Petri, Jr.

{dagger} Present address: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425.

{ddagger} Present address: Jinan University School of Medicine, Guangzhou 510632, China.

Infection and Immunity, December 2003, p. 7159-7163, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7159-7163.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cordeiro, C. A., Moreira, P. R., Andrade, M. S., Dutra, W. O., Campos, W. R., Orefice, F., Teixeira, A. L. (2008). Interleukin-10 Gene Polymorphism (-1082G/A) is Associated with Toxoplasmic Retinochoroiditis. IOVS 49: 1979-1982 [Abstract] [Full Text]  
  • Lu, F., Huang, S., Hu, M. S., Kasper, L. H. (2005). Experimental Ocular Toxoplasmosis in Genetically Susceptible and Resistant Mice. Infect. Immun. 73: 5160-5165 [Abstract] [Full Text]  
  • Kim, S.-K., Boothroyd, J. C. (2005). Stage-Specific Expression of Surface Antigens by Toxoplasma gondii as a Mechanism to Facilitate Parasite Persistence. J. Immunol. 174: 8038-8048 [Abstract] [Full Text]  
  • Lu, F., Huang, S., Kasper, L. H. (2004). CD4+ T Cells in the Pathogenesis of Murine Ocular Toxoplasmosis. Infect. Immun. 72: 4966-4972 [Abstract] [Full Text]  


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