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Infection and Immunity, December 2003, p. 7170-7172, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7170-7172.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Deletion of Mycobacterium tuberculosis Sigma Factor E Results in Delayed Time to Death with Bacterial Persistence in the Lungs of Aerosol-Infected Mice

Masaru Ando,{dagger} Tetsuyuki Yoshimatsu, Chiew Ko, Paul J. Converse, and William R. Bishai*

Department of Medicine, Center for Tuberculosis Research, Johns Hopkins School of Medicine, Baltimore, Maryland 21231

Received 9 June 2003/ Returned for modification 2 August 2003/ Accepted 8 August 2003

The stress-induced extracytoplasmic sigma factor E (SigE) of Mycobacterium tuberculosis shows increased expression after heat shock, sodium dodecyl sulfate treatment, and oxidative stress, as well as after phagocytosis in macrophages. We report that deletion of sigE results in delayed lethality in mice without a significant reduction of bacterial numbers in lungs.

* Corresponding author. Mailing address: Center for Tuberculosis Research, Johns Hopkins School of Medicine, Johns Hopkins University, 1503 E. Jefferson St., Baltimore, MD 21231-1001. Phone: (410) 955-3507. Fax: (410) 614-8173. E-mail: wbishai{at}jhsph.edu.

Editor: W. A. Petri, Jr.

{dagger} Present address: Division of Pulmonary Diseases, Department of Immunology and Allergy, Oita Medical University, Oita, Japan.

Infection and Immunity, December 2003, p. 7170-7172, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7170-7172.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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