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Infection and Immunity, December 2003, p. 7173-7177, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7173-7177.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

CD8+-T-Cell Responses of Mycobacterium-Infected Mice to a Newly Identified Major Histocompatibility Complex Class I-Restricted Epitope Shared by Proteins of the ESAT-6 Family

Laleh Majlessi,1* Marie-Jésus Rojas,1 Priscille Brodin,2 and Claude Leclerc1

Unité de Biologie des Régulations Immunitaires, INSERM E352,1 Unité de Génétique Moléculaire Bactérienne, Institut Pasteur, 75724 Paris Cedex 15, France2

Received 23 April 2003/ Returned for modification 10 June 2003/ Accepted 20 August 2003

Here we describe the identification of a new CD8+-T-cell epitope, the GYAGTLQSL nonamer, shared by the TB10.3 and TB10.4 proteins of the Mycobacterium tuberculosis ESAT-6 family. Cytotoxic T cells from mycobacterium-infected mice efficiently recognized this epitope. GYAGTLQSL-specific T-cell hybridomas, which were able to recognize Mycobacterium bovis BCG-infected macrophages, were generated and now allow investigation of mycobacterial-antigen processing through the major histocompatibility complex class I pathway.

* Corresponding author. Mailing address: Unité de Biologie des Régulations Immunitaires, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France. Phone: (33-1) 45.68.85.42. Fax: (33-1) 45.68.85.40. E-mail: lmajless{at}pasteur.fr.

Editor: S. H. E. Kaufmann

Infection and Immunity, December 2003, p. 7173-7177, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7173-7177.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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