This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Majlessi, L. Articles by Leclerc, C. Search for Related Content PubMed PubMed Citation Articles by Majlessi, L. Articles by Leclerc, C.

 Previous Article  |  Next Article 

Infection and Immunity, December 2003, p. 7173-7177, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7173-7177.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

CD8⁺-T-Cell Responses of Mycobacterium-Infected Mice to a Newly Identified Major Histocompatibility Complex Class I-Restricted Epitope Shared by Proteins of the ESAT-6 Family

Unité de Biologie des Régulations Immunitaires, INSERM E352,¹ Unité de Génétique Moléculaire Bactérienne, Institut Pasteur, 75724 Paris Cedex 15, France²

Received 23 April 2003/ Returned for modification 10 June 2003/ Accepted 20 August 2003

Here we describe the identification of a new CD8⁺-T-cell epitope, the GYAGTLQSL nonamer, shared by the TB10.3 and TB10.4 proteins of the Mycobacterium tuberculosis ESAT-6 family. Cytotoxic T cells from mycobacterium-infected mice efficiently recognized this epitope. GYAGTLQSL-specific T-cell hybridomas, which were able to recognize Mycobacterium bovis BCG-infected macrophages, were generated and now allow investigation of mycobacterial-antigen processing through the major histocompatibility complex class I pathway.

Editor: S. H. E. Kaufmann

This article has been cited by other articles:

• Woodworth, J. S., Fortune, S. M., Behar, S. M. (2008). Bacterial Protein Secretion Is Required for Priming of CD8+ T Cells Specific for the Mycobacterium tuberculosis Antigen CFP10. Infect. Immun. 76: 4199-4205 [Abstract] [Full Text]  
• Billeskov, R., Vingsbo-Lundberg, C., Andersen, P., Dietrich, J. (2007). Induction of CD8 T Cells against a Novel Epitope in TB10.4: Correlation with Mycobacterial Virulence and the Presence of a Functional Region of Difference-1. J. Immunol. 179: 3973-3981 [Abstract] [Full Text]  
• Radosevic, K., Wieland, C. W., Rodriguez, A., Weverling, G. J., Mintardjo, R., Gillissen, G., Vogels, R., Skeiky, Y. A. W., Hone, D. M., Sadoff, J. C., van der Poll, T., Havenga, M., Goudsmit, J. (2007). Protective Immune Responses to a Recombinant Adenovirus Type 35 Tuberculosis Vaccine in Two Mouse Strains: CD4 and CD8 T-Cell Epitope Mapping and Role of Gamma Interferon. Infect. Immun. 75: 4105-4115 [Abstract] [Full Text]  
• Majlessi, L., Combaluzier, B., Albrecht, I., Garcia, J. E., Nouze, C., Pieters, J., Leclerc, C. (2007). Inhibition of Phagosome Maturation by Mycobacteria Does Not Interfere with Presentation of Mycobacterial Antigens by MHC Molecules. J. Immunol. 179: 1825-1833 [Abstract] [Full Text]  
• Kamath, A., Woodworth, J. S.M., Behar, S. M. (2006). Antigen-Specific CD8+ T Cells and the Development of Central Memory during Mycobacterium tuberculosis Infection. J. Immunol. 177: 6361-6369 [Abstract] [Full Text]  
• Hervas-Stubbs, S., Majlessi, L., Simsova, M., Morova, J., Rojas, M.-J., Nouze, C., Brodin, P., Sebo, P., Leclerc, C. (2006). High Frequency of CD4+ T Cells Specific for the TB10.4 Protein Correlates with Protection against Mycobacterium tuberculosis Infection.. Infect. Immun. 74: 3396-3407 [Abstract] [Full Text]  
• Majlessi, L., Simsova, M., Jarvis, Z., Brodin, P., Rojas, M.-J., Bauche, C., Nouze, C., Ladant, D., Cole, S. T., Sebo, P., Leclerc, C. (2006). An Increase in Antimycobacterial Th1-Cell Responses by Prime-Boost Protocols of Immunization Does Not Enhance Protection against Tuberculosis. Infect. Immun. 74: 2128-2137 [Abstract] [Full Text]  
• Kamath, A. B., Woodworth, J., Xiong, X., Taylor, C., Weng, Y., Behar, S. M. (2004). Cytolytic CD8+ T Cells Recognizing CFP10 Are Recruited to the Lung after Mycobacterium tuberculosis Infection. J. Exp. Med. 200: 1479-1489 [Abstract] [Full Text]