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Infection and Immunity, December 2003, p. 7193-7196, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7193-7196.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The Activation of Bovine Plasminogen by PauA Is Not Required for Virulence of Streptococcus uberis

Philip N. Ward, Terence R. Field, Christopher D. Rapier, and James A. Leigh*

Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berks, United Kingdom RG20 7NN

Received 4 August 2003/ Returned for modification 26 August 2003/ Accepted 4 September 2003

A mutant of Streptococcus uberis carrying a single copy of ISS1 within pauA was unable to activate bovine plasminogen. Contrary to a hypothesis postulated previously, this mutation did not alter the ability of the bacterium to grow in milk or to infect the lactating bovine mammary gland.

* Corresponding author. Mailing address: Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berks, United Kingdom RG20 7NN. Phone: 44 (0)1635 577249. Fax: 44 (0)1635 577243. E-mail: james.leigh{at}bbsrc.ac.uk.

Editor: A. D. O'Brien

Infection and Immunity, December 2003, p. 7193-7196, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7193-7196.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Zadoks, R. N., Schukken, Y. H., Wiedmann, M. (2005). Multilocus Sequence Typing of Streptococcus uberis Provides Sensitive and Epidemiologically Relevant Subtype Information and Reveals Positive Selection in the Virulence Gene pauA. J. Clin. Microbiol. 43: 2407-2417 [Abstract] [Full Text]  


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