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Infection and Immunity, December 2003, p. 7202-7207, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7202-7207.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Genetic Analysis of the Capsule Locus of Haemophilus influenzae Serotype f

Atlanta Veterans Affairs Medical Center and Department of Medicine, Emory University School of Medicine, Decatur, Georgia 30033

Received 19 June 2003/ Returned for modification 18 July 2003/ Accepted 3 September 2003

A 19-kb DNA region containing genes involved in the biosynthesis of the capsule of Haemophilus influenzae serotype f (Hif) has been cloned and characterized. The Hif cap locus organization is typical of group II capsule biosynthetic loci found in other H. influenzae serotype b bacteria and other gram-negative bacteria. However, the Hif cap locus was not associated with an IS1016 element. Three new open reading frames, Fcs1, Fcs2, and Fcs3, were identified in the Hif capsule-specific region II. The chromosomal location of the Hif cap locus and the organization of the flanking sequences differed significantly from previously described division I H. influenzae serotypes.

Editor: J. N. Weiser

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