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Infection and Immunity, December 2003, p. 7215-7218, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7215-7218.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

High Levels of Susceptibility and T Helper 2 Response in MyD88-Deficient Mice Infected with Leishmania major Are Interleukin-4 Dependent

Andrea Debus, Joachim Gläsner, Martin Röllinghoff, and André Gessner*

Institut für Klinische Mikrobiologie, Immunologie und Hygiene der Universität Erlangen-Nürnberg, 91054 Erlangen, Germany

Received 28 March 2003/ Returned for modification 29 April 2003/ Accepted 14 August 2003

Myeloid differentiation protein 88 (MyD88) is a general adaptor for the signaling cascade through receptors of the Toll/IL-1R family. When infected with Leishmania major parasites, MyD88-deficient mice displayed a dramatically enhanced parasite burden in their tissues similar to that found in susceptible BALB/c mice. In contrast, MyD88 knockout mice did not develop ulcerating lesions despite a lack of interleukin-12 (IL-12) production and a predominant T helper 2 cell response. Blockade of IL-4 produced early (day 1) after infection restored a protective T helper 1 response in MyD88 knockout mice.

* Corresponding author. Mailing address: Institut für Klinische Mikrobiologie, Immunologie und Hygiene, Wasserturmstr. 3, D-91054 Erlangen, Germany. Phone: 09131/85-22580. Fax: 09131/85-22573. E-mail: gessner{at}mikrobio.med.uni-erlangen.de.

Editor: S. H. E. Kaufmann

Infection and Immunity, December 2003, p. 7215-7218, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7215-7218.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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