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Infection and Immunity, December 2003, p. 7228-7231, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7228-7231.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Enhanced Phagocytosis of Candida Species Mediated by Opsonization with a Recombinant Human Antibody Single-Chain Variable Fragment

Melanie Wellington,1,2 Joseph M. Bliss,1,{dagger} and Constantine G. Haidaris2,3*

Department of Pediatrics,1 Department of Microbiology and Immunology,2 Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 146423

Received 29 July 2003/ Returned for modification 8 August 2003/ Accepted 15 September 2003

Specific antibody opsonization significantly enhances the level of phagocytosis of Candida in the absence of complement. Furthermore, we have described a system using a recombinant human antibody single-chain variable fragment that allows a comparative study of phagocytosis of multiple Candida species opsonized via a common antigen.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave., Box 672, Rochester, NY 14642. Phone: (585) 275-0678. Fax: (585) 473-9573. E-mail: haid{at}mail.rochester.edu.

Editor: T. R. Kozel

{dagger} Present address: Department of Pediatrics, Women and Infants' Hospital of Rhode Island, Brown University School of Medicine, Providence, RI 02905.

Infection and Immunity, December 2003, p. 7228-7231, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7228-7231.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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