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Infection and Immunity, December 2003, p. 7232-7235, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7232-7235.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Lipopolysaccharide from the Periodontal Pathogen Porphyromonas gingivalis Prevents Apoptosis of HL60-Derived Neutrophils In Vitro

D. A Murray and J. M. A. Wilton*

Department of Adult Dental Health, Dental School, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XY, United Kingdom

Received 13 May 2003/ Returned for modification 8 July 2003/ Accepted 19 August 2003

Lipopolysaccharide (LPS) from Porphyromonas gingivalis prevented apoptosis of HL60-derived neutrophils, which could not be restored upon the addition of interleukin-10. Signaling of P. gingivalis LPS through Toll-like receptor 2 (TLR2), not TLR4, may account for the inhibiting effect of P. gingivalis LPS on apoptosis and provide a mechanism for the development of destructive periodontal inflammation.

* Corresponding author. Mailing address: Department of Adult Dental Health, Dental School, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XY, United Kingdom. Phone: 029 20744356. Fax: 029 20743120. E-mail: WiltonMJ{at}cardiff.ac.uk.

Editor: A. D. O'Brien

Infection and Immunity, December 2003, p. 7232-7235, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7232-7235.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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