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Infection and Immunity, February 2003, p. 1001-1007, Vol. 71, No. 2
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.2.1001-1007.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Regulation of Expression of the Borrelia burgdorferi ß3-Chain Integrin Ligand, P66, in Ticks and in Culture

Carla Cugini,1 Melisa Medrano,2 Tom G. Schwan,3 and Jenifer Coburn1,2*

Department of Medicine, Division of Geographic Medicine and Infectious Diseases, Tufts-New England Medical Center,1 Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts,2 Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana3

Received 9 July 2002/ Returned for modification 23 August 2002/ Accepted 31 October 2002

Borrelia burgdorferi is maintained in an infection cycle between mammalian and arthropod hosts. Appropriate gene expression by B. burgdorferi at different stages of this cycle is probably essential for transmission and establishment of infection. The B. burgdorferi ß3 integrin ligand P66 is expressed by the bacteria in mammals, laboratory culture, and engorged but not unfed ticks. No in vitro culture conditions in which P66 expression reflected that in the unfed tick were found, suggesting that there are aspects of B. burgdorferi-tick interaction that remain unexplored.

* Corresponding author. Mailing address: NEMC Box 41, Division of Geographic Medicine and Infectious Diseases, Tufts-New England Medical Center, 750 Washington St., Boston, MA. Phone: (617) 636-5952. Fax: (617) 636-5292. E-mail: jcoburn{at}lifespan.org.

Editor: J. T. Barbieri

Infection and Immunity, February 2003, p. 1001-1007, Vol. 71, No. 2
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.2.1001-1007.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Medrano, M. S., Policastro, P. F., Schwan, T. G., Coburn, J. (2009). Interaction of Borrelia burgdorferi Hbb with the p66 promoter. Nucleic Acids Res 0: gkp1027v1-gkp1027 [Abstract] [Full Text]  
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