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Infection and Immunity, February 2003, p. 1011-1015, Vol. 71, No. 2
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.2.1011-1015.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Modulation of J774.1 Macrophage L-Arginine Metabolism by Intracellular Mycobacterium bovis BCG

Marcy A. Peteroy-Kelly,1,2,3,{dagger} Vishwanath Venketaraman,1,2,3,4 Meliza Talaue,1,2,3 Anjali Seth,1,2,3 and Nancy D. Connell1,2,3,4*

Department of Microbiology and Molecular Genetics,1 National Tuberculosis Center, Department of Medicine,2 Center for Emerging and Reemerging Pathogens,3 International Center for Public Health, UMDNJ/New Jersey Medical School, Newark, New Jersey 07101-17094

Received 30 January 2002/ Returned for modification 26 March 2002/ Accepted 7 November 2002

Using a Mycobacterium bovis BCG mutant (AS1) lacking a Bacillus subtilis L-arginine transporter homolog, we demonstrate here that the interaction between intracellular mycobacteria and the macrophage with respect to L-arginine transport and metabolism is quite complex. Intracellular AS1 stimulates macrophage L-arginine transport and accumulates 2.5-fold more 3H label derived from L-arginine than does the wild type. These studies suggest that the accumulation of 3H label reflects the acquisition of metabolites of L-arginine produced by the macrophage.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, International Center for Public Health, UMDNJ/New Jersey Medical School, 225 Warren St., Newark, NJ 07101-1709. Phone: (973) 972-3759. Fax: (973)-972-3644. E-mail: connell{at}umdnj.edu.

Editor: S. H. E. Kaufmann

{dagger} Present address: School of Theoretical and Applied Sciences, Ramapo College of New Jersey, Mahwah, NJ 07430.

Infection and Immunity, February 2003, p. 1011-1015, Vol. 71, No. 2
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.2.1011-1015.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Talaue, M. T., Venketaraman, V., Hazbon, M. H., Peteroy-Kelly, M., Seth, A., Colangeli, R., Alland, D., Connell, N. D. (2006). Arginine Homeostasis in J774.1 Macrophages in the Context of Mycobacterium bovis BCG Infection. J. Bacteriol. 188: 4830-4840 [Abstract] [Full Text]  
  • Yeramian, A., Martin, L., Serrat, N., Arpa, L., Soler, C., Bertran, J., McLeod, C., Palacin, M., Modolell, M., Lloberas, J., Celada, A. (2006). Arginine Transport via Cationic Amino Acid Transporter 2 Plays a Critical Regulatory Role in Classical or Alternative Activation of Macrophages. J. Immunol. 176: 5918-5924 [Abstract] [Full Text]  


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