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Infection and Immunity, February 2003, p. 597-604, Vol. 71, No. 2
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.2.597-604.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Plasmodium falciparum Infection Elicits Both Variant-Specific and Cross-Reactive Antibodies against Variant Surface Antigens

Rana Chattopadhyay,1,{dagger} Amit Sharma,1 Vinod K. Srivastava,2 Sudhanshu S. Pati,2 S. K. Sharma,3 Bhabani S. Das,2 and Chetan E. Chitnis1*

Malaria Research Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi,1 Department of Biochemistry, Ispat General Hospital (IGH),2 Malaria Research Centre Field Station, Rourkela, India3

Received 2 January 2002/ Returned for modification 25 February 2002/ Accepted 12 June 2002

Naturally acquired antibodies to Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1), the variant surface antigens expressed on the surface of infected erythrocytes, are thought to play a role in protection against P. falciparum malaria. Here, we have studied the development of antibodies to PfEMP-1 in adult malaria patients living in Rourkela, India, an area with a low malaria transmission rate, and prevalence of antibodies to PfEMP-1 in residents of San Dulakudar, India, a village in which P. falciparum malaria is hyperendemic. Convalescent-phase sera from adult malaria patients from Rourkela agglutinate homologous P. falciparum isolates as well as some heterologous isolates, suggesting that they develop partially cross-reactive antibodies to PfEMP-1 following infection. Adult sera from San Dulakudar agglutinate diverse P. falciparum isolates, suggesting that they have antibodies with wide recognition of diverse PfEMP-1. Mixed-agglutination assays using pairs of P. falciparum isolates confirm the presence of both variant-specific and partially cross-reactive antibodies in convalescent-phase sera from Rourkela and adult sera from San Dulakudar. Analysis of PfEMP-1 sequences suggests a molecular basis for the observed cross-reactivity.

* Corresponding author. Mailing address: Malaria Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), P.O. Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India. Phone: 91 11 618 7695. Fax: 91 11 616 2316. E-mail: cchitnis{at}icgeb.res.in.

Editor: S. H. E. Kaufmann

{dagger} Present address: Naval Medical Research Centre, Silver Spring, MD 20910-7500.

Infection and Immunity, February 2003, p. 597-604, Vol. 71, No. 2
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.2.597-604.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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