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Infection and Immunity, February 2003, p. 733-738, Vol. 71, No. 2
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.2.733-738.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Role of Systemic and Mucosal Immune Responses in Reciprocal Protection against Bordetella pertussis and Bordetella parapertussis in a Murine Model of Respiratory Infection

Mineo Watanabe1* and Masaaki Nagai2

Department of Microbiology and Biologicals, Daiichi College of Pharmaceutical Sciences, Fukuoka 815-8511,1 Research Center for Biologicals, The Kitasato Institute, Kitamoto 364-0026, Japan2

Received 26 August 2002/ Returned for modification 23 October 2002/ Accepted 14 November 2002

The roles of systemic humoral immunity, cell-mediated immunity, and mucosal immunity in reciprocal protective immunity against Bordetella pertussis and Bordetella parapertussis were examined by using a murine model of respiratory infection. Passive immunization with serum from mice infected with B. pertussis established protective immunity against B. pertussis but not against B. parapertussis. Protection against B. parapertussis was induced in mice that had been injected with serum from mice infected with B. parapertussis but not from mice infected with B. pertussis. Adoptive transfer of spleen cells from mice infected with B. pertussis or B. parapertussis also failed to confer reciprocal protection. To examine the role of mucosal immunity in reciprocal protection, mice were infected with preparations of either B. pertussis or B. parapertussis, each of which had been incubated with the bronchoalveolar wash of mice that were convalescing after infection with B. pertussis or B. parapertussis. Such incubation conferred reciprocal protection against B. pertussis and B. parapertussis on infected mice. The data suggest that mucosal immunity including secreted immunoglobulin A in the lungs might play an important role in reciprocal protective immunity in this murine model of respiratory infection.

* Corresponding author. Mailing address: Department of Microbiology and Biologicals, Daiichi College of Pharmaceutical Sciences, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan. Phone: 81-92-541-0161. Fax: 81-92-553-5698. E-mail: min-ind{at}umin.ac.jp.

Editor: J. D. Clements

Infection and Immunity, February 2003, p. 733-738, Vol. 71, No. 2
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.2.733-738.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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