This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chu, H. W.
Right arrow Articles by Martin, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chu, H. W.
Right arrow Articles by Martin, R. J.

 Previous Article  |  Next Article 

Infection and Immunity, March 2003, p. 1520-1526, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1520-1526.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Effects of Respiratory Mycoplasma pneumoniae Infection on Allergen-Induced Bronchial Hyperresponsiveness and Lung Inflammation in Mice

Hong Wei Chu, Joyce M. Honour, Catherine A. Rawlinson, Ronald J. Harbeck, and Richard J. Martin*

Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado

Received 4 October 2002/ Returned for modification 14 November 2002/ Accepted 26 November 2002

Airway mycoplasma infection may be associated with asthma pathophysiology. However, the direct effects of mycoplasma infection on asthma remain unknown. Using a murine allergic-asthma model, we evaluated the effects of different timing of airway Mycoplasma pneumoniae infection on bronchial hyperresponsiveness (BHR), lung inflammation, and the protein levels of Th1 (gamma interferon [IFN-{gamma}]) and Th2 (interleukin 4 [IL-4]) cytokines in bronchoalveolar lavage fluid. When mycoplasma infection occurred 3 days before allergen (ovalbumin) sensitization and challenge, the infection reduced the BHR and inflammatory-cell influx into the lung. This was accompanied by a significant induction of Th1 responses (increased IFN-{gamma} and decreased IL-4 production). Conversely, when mycoplasma infection occurred 2 days after allergen sensitization and challenge, the infection initially caused a temporary reduction of BHR and then increased BHR, lung inflammation, and IL-4 levels. Our data suggest that mycoplasma infection could modulate both physiological and immunological responses in the murine asthma model. Our animal models may also provide a new means to understand the role of infection in asthma pathogenesis and give evidence for the asthma hygiene hypothesis.

* Corresponding author. Mailing address: National Jewish Medical and Research Center, 1400 Jackson St., Room B116, Denver, CO 80206. Phone: (303) 398-1545. Fax: (303) 398-1780. E-mail: martinr{at}njc.org.

Editor: J. N. Weiser

Infection and Immunity, March 2003, p. 1520-1526, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1520-1526.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ledford, J. G., Goto, H., Potts, E. N., Degan, S., Chu, H. W., Voelker, D. R., Sunday, M. E., Cianciolo, G. J., Foster, W. M., Kraft, M., Wright, J. R. (2009). SP-A Preserves Airway Homeostasis During Mycoplasma pneumoniae Infection in Mice. J. Immunol. 182: 7818-7827 [Abstract] [Full Text]  
  • Sutherland, E. R., Martin, R. J. (2007). Asthma and Atypical Bacterial Infection. Chest 132: 1962-1966 [Abstract] [Full Text]  
  • Chu, H. W., Thaikoottathil, J., Rino, J. G., Zhang, G., Wu, Q., Moss, T., Refaeli, Y., Bowler, R., Wenzel, S. E., Chen, Z., Zdunek, J., Breed, R., Young, R., Allaire, E., Martin, R. J. (2007). Function and Regulation of SPLUNC1 Protein in Mycoplasma Infection and Allergic Inflammation. J. Immunol. 179: 3995-4002 [Abstract] [Full Text]  
  • Wu, Q., Martin, R. J., Rino, J. G., Jeyaseelan, S., Breed, R., Chu, H. W. (2007). A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 292: L1064-L1072 [Abstract] [Full Text]  
  • Salvatore, C. M., Fonseca-Aten, M., Katz-Gaynor, K., Gomez, A. M., Mejias, A., Somers, C., Chavez-Bueno, S., McCracken, G. H., Hardy, R. D. (2007). Respiratory Tract Infection with Mycoplasma pneumoniae in Interleukin-12 Knockout Mice Results in Improved Bacterial Clearance and Reduced Pulmonary Inflammation. Infect. Immun. 75: 236-242 [Abstract] [Full Text]  
  • Xu, X., Zhang, D., Zhang, H., Wolters, P. J., Killeen, N. P., Sullivan, B. M., Locksley, R. M., Lowell, C. A., Caughey, G. H. (2006). Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. JEM 203: 2907-2917 [Abstract] [Full Text]  
  • Singh, A M, Busse, W W (2006). Asthma exacerbations {middle dot} 2: Aetiology. Thorax 61: 809-816 [Abstract] [Full Text]  
  • Johnston, S. L., Martin, R. J. (2005). Chlamydophila pneumoniae and Mycoplasma pneumoniae: A Role in Asthma Pathogenesis?. Am. J. Respir. Crit. Care Med. 172: 1078-1089 [Abstract] [Full Text]  
  • Chu, H. W., Rino, J. G., Wexler, R. B., Campbell, K., Harbeck, R. J., Martin, R. J. (2005). Mycoplasma pneumoniae infection increases airway collagen deposition in a murine model of allergic airway inflammation. Am. J. Physiol. Lung Cell. Mol. Physiol. 289: L125-L133 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»