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Infection and Immunity, March 2003, p. 1566-1568, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1566-1568.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Role of Interleukin-6 in the Control of Acute and Chronic Giardia lamblia Infections in Mice

Ping Zhou,1 Erqiu Li,1 Nannan Zhu,1 Jason Robertson,1 Theodore Nash,2 and Steven M. Singer1*

Department of Biology, Georgetown University, Washington, D.C. 20057,1 Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20896-04522

Received 2 July 2002/ Returned for modification 17 September 2002/ Accepted 19 November 2002

In this study, we investigated the role of interleukin-6 (IL-6) in Giardia lamblia infections in mice. Elevated IL-6 expression was found in wild-type mice 15 days postinfection. Furthermore, IL-6-deficient mice controlled infections only slowly although normal immunoglobulin A production was observed. Thus, IL-6 is necessary for early control of acute G. lamblia infections.

* Corresponding author. Mailing address: Department of Biology, Reiss Science Bldg., Rm. 307, Georgetown University, Washington, DC 20057. Phone: (202) 687-9884. Fax: (202) 687-5662. E-mail: sms3{at}georgetown.edu.

Editor: J. M. Mansfield

Infection and Immunity, March 2003, p. 1566-1568, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1566-1568.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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