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Infection and Immunity, March 2003, p. 1569-1573, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1569-1573.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Interleukin-6-Deficient Mice Are Highly Susceptible to Giardia lamblia Infection but Exhibit Normal Intestinal Immunoglobulin A Responses against the Parasite

Marianne Bienz,1 Wen Juan Dai,2 Monika Welle,3 Bruno Gottstein,1 and Norbert Müller1*

Institute of Parasitology,1 Clinic for Rheumatology and Clinical Immunology/Allergology,2 Institute of Veterinary Pathology, University of Berne, Berne, Switzerland3

Received 17 June 2002/ Returned for modification 17 September 2002/ Accepted 19 November 2002

In the present study, interleukin-6 (IL-6)-deficient mice were infected with Giardia lamblia clone GS/M-83-H7. Murine IL-6 deficiency did not affect the synthesis of parasite-specific intestinal immunoglobulin A. However, in contrast to wild-type mice, IL-6-deficient animals were not able to control the acute phase of parasite infection. Reverse transcription-PCR-based quantitation of cytokine mRNA levels in peripheral lymph node cells exhibited a short-term up-regulation of IL-4 expression in IL-6-deficient mice that seemed to be associated with failure in controlling the parasite population. This observation suggests a further elucidation of IL-4-dependent, Th2-type regulatory processes regarding their potential to influence the course of G. lamblia infection in the experimental murine host.

* Corresponding author. Mailing address: Institute of Parasitology, University of Berne, Länggassstrasse 122, CH-3001 Berne, Switzerland. Phone: (4131) 6312384. Fax: (4131) 6312622. E-mail: nmueller{at}ipa.unibe.ch.

Editor: J. M. Mansfield

Infection and Immunity, March 2003, p. 1569-1573, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1569-1573.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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