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Infection and Immunity, March 2003, p. 1574-1579, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1574-1579.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Nonhuman Primate Model for Listeria monocytogenes-Induced Stillbirths

Mary Alice Smith,1* Kazue Takeuchi,2 Robert E. Brackett,2,{dagger} Harold M. McClure,3 Richard B. Raybourne,4 Kristina M. Williams,4 Uma S. Babu,4 Glenn O. Ware,5 J. Roger Broderson,6 and Michael P. Doyle2

Department of Environmental Health Science,1 Experimental Statistics,5 Office of the Vice President for Research, University of Georgia, Athens, Georgia 30602,6 Center for Food Safety, University of Georgia, Griffin, Georgia 30223,2 Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322,3 U.S. Food and Drug Administration, Laurel, Maryland 207084

Received 5 August 2002/ Returned for modification 12 September 2002/ Accepted 23 November 2002

Listeria monocytogenes, isolated from outbreaks in either human or nonhuman primate populations, was administered orally at doses ranging from 106 to 1010 CFU. Four of 10 treated animals delivered stillborn infants. L. monocytogenes was isolated from fetal tissue, and the pathology was consistent with L. monocytogenes infection as the cause of pregnancy loss. For all pregnancies resulting in stillbirths, L. monocytogenes was isolated from maternal feces, indicating that L. monocytogenes had survived and had probably colonized the gastrointestinal tract. Antibodies and antigen-specific lymphocyte proliferation against Listeria increased in animals that had stillbirths.

* Corresponding author. Mailing address: 206 Environmental Health Science Building, University of Georgia, Athens, GA 30602-2102. Phone: (706) 542-2454. Fax: (706) 542-7472. E-mail: masmith{at}uga.edu.

Editor: J. D. Clements

{dagger} Present address: U.S. Food and Drug Administration, College Park, MD 20740.

Infection and Immunity, March 2003, p. 1574-1579, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1574-1579.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Smith, M. A., Takeuchi, K., Anderson, G., Ware, G. O., McClure, H. M., Raybourne, R. B., Mytle, N., Doyle, M. P. (2008). Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates. Infect. Immun. 76: 726-731 [Abstract] [Full Text]  
  • Sahu, S. C., Gaines, D. W., Williams, K. M., Raybourne, R. B. (2007). A synthetic polypeptide based on human E-cadherin inhibits invasion of human intestinal and liver cell lines by Listeria monocytogenes. J Med Microbiol 56: 1011-1016 [Abstract] [Full Text]  
  • Zhao, X., Li, Z., Gu, B., Frankel, F. R. (2005). Pathogenicity and Immunogenicity of a Vaccine Strain of Listeria monocytogenes That Relies on a Suicide Plasmid To Supply an Essential Gene Product. Infect. Immun. 73: 5789-5798 [Abstract] [Full Text]  


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