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Infection and Immunity, March 2003, p. 1584-1586, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1584-1586.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Expression of Variant Surface Antigens by Plasmodium falciparum Parasites in the Peripheral Blood of Clinically Immune Pregnant Women Indicates Ongoing Placental Infection

Michael F. Ofori,1,2 Trine Staalsoe,2 Victoria Bam,3 Maja Lundquist,2 Kim P. David,2 Edmund N. L. Browne,3 Bartholomew D. Akanmori,1 and Lars Hviid2*

Immunology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon,1 Department of Community Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana,3 Centre for Medical Parasitology, Department of Infectious Diseases, Department of Clinical Microbiology, Copenhagen University Hospital (Rigshospitalet), and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark2

Received 17 September 2002/ Returned for modification 1 November 2002/ Accepted 25 November 2002

Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSAPAM) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSAPAM, making them a convenient source of VSAPAM expressors for PAM vaccine research.

* Corresponding author. Mailing address: Department of Infectious Diseases M7641, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark. Phone: 45 35 45 79 57. Fax: 45 35 45 76 44. E-mail: lhcmp{at}rh.dk.

Editor: W. A. Petri, Jr.

Infection and Immunity, March 2003, p. 1584-1586, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1584-1586.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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