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Infection and Immunity, April 2003, p. 2226-2229, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2226-2229.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Passive Immunity in Helicobacter-Challenged Neonatal Mice Conferred by Immunized Dams Lasts until Weaning

Irène Corthésy-Theulaz,1,2* Blaise Corthésy,3 Daniel Bachmann,1 Dominique Velin,4 and Jean-Pierre Kraehenbuhl4

Division of Gastroenterology,1 Nestlé Research Center,2 Division of Immunology and Allergy, CHUV, Lausanne,3 Swiss Institute for Experimental Cancer Research and Biochemistry Institute, University of Lausanne, Epalinges, Switzerland4

Received 9 August 2002/ Returned for modification 1 November 2002/ Accepted 18 December 2002

The objective of this study was to examine the effect of breast-feeding by immunized dams on Helicobacter colonization in newborns. Urease-based immunization regimens failed to protect nursing pups against H. felis, whereas H. felis lysate-cholera toxin resulted in protection. This observation correlated with a high recognition of cell surface-expressed bacterial antigens by milk antibodies. Protection lasted until weaning, indicating that infection is maintained at undetectable levels by passive immunity but then resumes when breast-feeding stops.

* Corresponding author. Present address: Nestlé Research Center, CH-1000 Lausanne 26, Switzerland. Phone: (41) 21 785 84 32. Fax: (41) 21 785 89 25. E-mail: irene.corthesy{at}rdls.nestle.com.

Editor: A. D. O'Brien

Infection and Immunity, April 2003, p. 2226-2229, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2226-2229.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gorrell, R. J., Robins-Browne, R. M. (2009). Antibody-Mediated Protection against Infection with Helicobacter pylori in a Suckling Mouse Model of Passive Immunity. Infect. Immun. 77: 5116-5129 [Abstract] [Full Text]  


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