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Infection and Immunity, April 2003, p. 2234-2238, Vol. 71, No. 4
0019-9567/03/$08.00+0 DOI: 10.1128/IAI.71.4.2234-2238.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.
Synergistic Protection of Mice against Plague with Monoclonal Antibodies Specific for the F1 and V Antigens of Yersinia pestis
Jim Hill,* Catherine Copse,
Sophie Leary, Anthony J. Stagg, E. Diane Williamson, and Richard W. Titball
Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom
Received 6 August 2002/
Returned for modification 26 September 2002/
Accepted 11 December 2002
Monoclonal antibodies specific for Yersinia pestis V antigen and F1 antigen, administered singly or in combination, protected mice in models of bubonic and pneumonic plague. Antibodies showed synergy when administered prophylactically and as a therapy 48 h postinfection. Monoclonal antibodies therefore have potential as a treatment for plague.
* Corresponding author. Mailing address: Defense Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom. Phone: 44 1980 614756. Fax: 44 1980 614 307. E-mail: jhill{at}dstl.gov.uk.
Editor: D. L. Burns
Present address: Amersham Biosciences, Amersham, Buckinghamshire HP7 9LL, United Kingdom.
Infection and Immunity, April 2003, p. 2234-2238, Vol. 71, No. 4
0019-9567/03/$08.00+0 DOI: 10.1128/IAI.71.4.2234-2238.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.
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Copyright © 2003 by the American Society for Microbiology. All rights reserved.