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Infection and Immunity, April 2003, p. 2234-2238, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2234-2238.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Synergistic Protection of Mice against Plague with Monoclonal Antibodies Specific for the F1 and V Antigens of Yersinia pestis

Jim Hill,* Catherine Copse,{dagger} Sophie Leary, Anthony J. Stagg, E. Diane Williamson, and Richard W. Titball

Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom

Received 6 August 2002/ Returned for modification 26 September 2002/ Accepted 11 December 2002

Monoclonal antibodies specific for Yersinia pestis V antigen and F1 antigen, administered singly or in combination, protected mice in models of bubonic and pneumonic plague. Antibodies showed synergy when administered prophylactically and as a therapy 48 h postinfection. Monoclonal antibodies therefore have potential as a treatment for plague.

* Corresponding author. Mailing address: Defense Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom. Phone: 44 1980 614756. Fax: 44 1980 614 307. E-mail: jhill{at}dstl.gov.uk.

Editor: D. L. Burns

{dagger} Present address: Amersham Biosciences, Amersham, Buckinghamshire HP7 9LL, United Kingdom.

Infection and Immunity, April 2003, p. 2234-2238, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2234-2238.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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