This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Suvarnapunya, A. E.
Right arrow Articles by Stein, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Suvarnapunya, A. E.
Right arrow Articles by Stein, M. A.

 Previous Article  |  Next Article 

Infection and Immunity, April 2003, p. 2247-2252, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2247-2252.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of the Prototrophic Salmonella Mutants Defective for Intraepithelial Replication

Akamol E. Suvarnapunya,1 Daniel V. Zurawski,1 Rebecca L. Guy,2 and Murry A. Stein1*

Departments of Microbiology & Molecular Genetics and Animal Sciences,1 Department of Pharmacology, University of Vermont, Burlington, Vermont 054052

Received 1 November 2002/ Accepted 18 December 2002

Three MudJ prototrophs demonstrated that intracellular replication is a Salmonella virulence trait (K. Y. Leung and B. B. Finlay, Proc. Natl. Acad. Sci. USA, 88:11470-11474, 1991). mutS and mutH are disrupted in mutants 3-11 and 12-23, and ssaQ is disrupted in mutant 17-21. Further analysis revealed that loss of Salmonella pathogenicity island 2 function underlies the intracellular replication defect of 3-11 and 17-21.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, University of Vermont, 95 Carrigan Dr., 118 Stafford Hall, Burlington, VT 05405-0068. Phone: (802) 656-5727. Fax: (802) 656-8749. E-mail: mastein{at}zoo.uvm.edu.

Editor: A. D. O'Brien

Infection and Immunity, April 2003, p. 2247-2252, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2247-2252.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Suvarnapunya, A. E., Stein, M. A. (2005). DNA base excision repair potentiates the protective effect of Salmonella Pathogenicity Island 2 within macrophages. Microbiology 151: 557-567 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»