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Infection and Immunity, April 2003, p. 2253-2257, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2253-2257.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Neisseria meningitidis RTX Proteins Are Not Required for Virulence in Infant Rats

Stanislav Forman,1 Irena Linhartova,1 Radim Osicka,1 Xavier Nassif,2 Peter Sebo,1 and Vladimir Pelicic2*

Laboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the Czech Academy of Sciences, CZ-142 20 Prague 4, Czech Republic,1 INSERM U570, Faculté de Médecine Necker-Enfants Malades, 75015 Paris, France2

Received 26 November 2002/ Returned for modification 19 December 2002/ Accepted 10 January 2003

RTX cytotoxins play an important role in virulence of numerous gram-negative pathogens. Unexpectedly, however, we show here that the RTX proteins of Neisseria meningitidis are dispensable for virulence in the infant rat model of infection.

* Corresponding author. Mailing address: INSERM U570, Faculté de Médecine Necker-Enfants Malades, 156 rue de Vaugirard, 75015 Paris, France. Phone: (33 1) 40615482. Fax: (33 1) 40615592. E-mail: pelicic{at}necker.fr.

Editor: D. L. Burns

Infection and Immunity, April 2003, p. 2253-2257, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2253-2257.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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