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Infection and Immunity, April 2003, p. 2258-2261, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2258-2261.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Vector Priming Reduces the Immunogenicity of Salmonella-Based Vaccines in Nramp1+/+ Mice

Christofer J. Vindurampulle{dagger} and Stephen R. Attridge*

Department of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia 5005, Australia

Received 9 September 2002/ Returned for modification 26 November 2002/ Accepted 3 January 2003

The present studies in Nramp1-/- BALB/c and Nramp1+/+ CBA mice question the significance of this genotype as a determinant of the level of gut colonization following oral administration of naturally attenuated or highly virulent Salmonella strains. In line with previous results in BALB/c hosts, vector priming of CBA mice with Salmonella enterica serovar Stanley was found to significantly compromise the immunogenicity of a recombinant construct expressing a foreign pilus protein.

* Corresponding author. Mailing address: Department of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia 5005, Australia. Phone: 61-8-83034150. Fax: 61-8-83037532. E-mail: stephen.attridge{at}adelaide.edu.au.

Editor: J. D. Clements

{dagger} Present address: Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Md.

Infection and Immunity, April 2003, p. 2258-2261, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2258-2261.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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