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Infection and Immunity, April 2003, p. 2276-2279, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2276-2279.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Interleukin-10 Negatively Regulates Local Cytokine and Chemokine Production but Does Not Influence Antibacterial Host Defense during Murine Pneumococcal Meningitis

Petra J. G. Zwijnenburg,1,2* Tom van der Poll,2 Sandrine Florquin,3 John J. Roord,1 and A. Marceline van Furth1,2

Department of Pediatrics, Vrije Universiteit Medical Center,1 Departments of Experimental Internal Medicine,2 Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands3

Received 1 August 2002/ Returned for modification 16 September 2002/ Accepted 16 December 2002

To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced.

* Corresponding author. Mailing address: Department of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Phone: 31-20-5666034. Fax: 31-20-6977192. E-mail: p.j.zwijnenburg{at}amc.uva.nl.

Editor: S. H. E. Kaufmann

Infection and Immunity, April 2003, p. 2276-2279, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2276-2279.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chiavolini, D., Pozzi, G., Ricci, S. (2008). Animal Models of Streptococcus pneumoniae Disease. Clin. Microbiol. Rev. 21: 666-685 [Abstract] [Full Text]  
  • Zwijnenburg, P. J. G., van der Poll, T., Roord, J. J., van Furth, A. M. (2006). Chemotactic Factors in Cerebrospinal Fluid during Bacterial Meningitis. Infect. Immun. 74: 1445-1451 [Full Text]  


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