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Infection and Immunity, April 2003, p. 2280-2282, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2280-2282.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Flagellum-Mediated Adhesion by Burkholderia pseudomallei Precedes Invasion of Acanthamoeba astronyxis

Timothy J. J. Inglis,1,2* Terry Robertson,3 Donald E. Woods,4 Nichole Dutton,3 and Barbara J. Chang1

Department of Microbiology,1 Electron Microscopy Unit, Division of Pathology, Department of Surgery and Pathology, Faculty of Medicine and Dentistry, University of Western Australia,3 Division of Microbiology and Infectious Diseases, Western Australian Centre for Pathology and Medical Research, Nedlands, Western Australia, Australia,2 Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada4

Received 15 August 2002/ Returned for modification 6 November 2002/ Accepted 2 January 2003

In this study we investigated the role of the bacterial flagellum in Burkholderia pseudomallei entry to Acanthamoeba astronyxis trophozoites. B. pseudomallei cells were tethered to the external amoebic surface via their flagella. MM35, the flagellum-lacking fliC knockout derivative of B. pseudomallei NCTC 1026b did not demonstrate flagellum-mediated endocytosis in timed coculture, confirming that an intact flagellar apparatus assists B. pseudomallei entry into A. astronyxis.

* Corresponding author. Mailing address: Division of Microbiology and Infectious Diseases, Western Australian Centre for Pathology and Medical Research (PathCentre), Locked Bag, Nedlands, WA 6909, Australia. Phone: 618 9346 3461. Fax: 618 9381 7139. E-mail: tim.inglis{at}health.wa.gov.au.

Editor: J. D. Clements

Infection and Immunity, April 2003, p. 2280-2282, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2280-2282.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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