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Infection and Immunity, April 2003, p. 2283-2287, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2283-2287.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Immunization with Porphyromonas gingivalis Capsular Polysaccharide Prevents P. gingivalis-Elicited Oral Bone Loss in a Murine Model

Dario Gonzalez,1 Arthur O. Tzianabos,2 Caroline A. Genco,3,4 and Frank C. Gibson III3*

Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Section of Infectious Diseases,1 Department of Medicine, Evan's Biomedical Research Center,3 Department of Microbiology, Boston University Medical Center, and Channing Laboratory, Brigham and Women's Hospital,4 Harvard Medical School, Boston, Massachusetts2

Received 4 November 2002/ Returned for modification 6 December 2002/ Accepted 9 January 2003

The capsular polysaccharide (CPS) of the periodontal pathogen Porphyromonas gingivalis is an important virulence factor for this organism. We purified P. gingivalis CPS, immunized mice with this antigen, and assessed the vaccine potential of P. gingivalis CPS by using the murine oral challenge model. Animals immunized with P. gingivalis CPS developed elevated levels of immunoglobulin M (IgM) and IgG in serum that reacted with whole P. gingivalis organisms. The mice immunized with P. gingivalis CPS were protected from P. gingivalis-elicited oral bone loss. These data demonstrate that P. gingivalis CPS is a vaccine candidate for prevention of P. gingivalis-elicited oral bone loss.

* Corresponding author. Mailing address: Evan's Biomedical Research Center, Room 635, Boston University Medical Center, 650 Albany St., Boston, MA 02118. Phone: (617) 414-5258. Fax: (617) 414-5280. E-mail: frank.gibson{at}bmc.org.

Editor: J. D. Clements

Infection and Immunity, April 2003, p. 2283-2287, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2283-2287.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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