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Infection and Immunity, May 2003, p. 2907-2910, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2907-2910.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Molecular Patchwork: Chromosomal Recombination between Two Helicobacter pylori Strains during Natural Colonization

Leonard C. Smeets,1* Nicolaas L. A. Arents,2 Anton A. van Zwet,2 Christina M. J. E. Vandenbroucke-Grauls,1 Theo Verboom,1 Wilbert Bitter,1 and Johannes G. Kusters1,3

Department of Medical Microbiology and Infection Control, Vrije Universiteit Medical Center, Amsterdam,1 Department of Medical Microbiology, Bethesda Hospital, Hoogeveen,2 Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands3

Received 7 October 2002/ Returned for modification 17 January 2003/ Accepted 5 February 2003

Genetic analysis of two Helicobacter pylori strains isolated from a single gastric biopsy showed evidence of extensive horizontal gene transfer. Several large recombinations were identified in the rdxA gene, which is involved in metronidazole resistance.

* Corresponding author. Mailing address: Department of Medical Microbiology and Infection Control, Vrije Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands. Phone: 31 20 4448310. Fax: 31 20 4448318. E-mail: lc.smeets{at}vumc.nl.

Editor: J. T. Barbieri

Infection and Immunity, May 2003, p. 2907-2910, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2907-2910.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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