This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wanken, A. E.
Right arrow Articles by Eaton, K. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wanken, A. E.
Right arrow Articles by Eaton, K. A.

 Previous Article  |  Next Article 

Infection and Immunity, May 2003, p. 2920-2923, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2920-2923.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The Entner-Doudoroff Pathway Has Little Effect on Helicobacter pylori Colonization of Mice

Amy E. Wanken,1 Tyrrell Conway,2,{dagger} and Kathryn A. Eaton1*

Department of Veterinary Biosciences,1 Department of Microbiology, Ohio State University, Columbus, Ohio 432102

Received 11 December 2002/ Returned for modification 9 January 2003/ Accepted 6 February 2003

Helicobacter pylori mutants deficient in 6-phosphogluconate dehydratase (6PGD) were constructed. Colonization densities were lower and minimum infectious doses were higher for mutant strains than for wild-type strains. In spite of better colonization, however, wild-type strains did not displace the mutant in cocolonization experiments. Loss of 6PGD diminishes the fitness of H. pylori in vivo, but the pathway is nonessential for colonization.

* Corresponding author. Mailing address: Department of Veterinary Biosciences, Ohio State University, Goss Laboratory, 1925 Coffey Rd., Columbus, OH 43210. Phone: (614) 292-9667. Fax: (614) 292-6473. E-mail: eaton.1{at}osu.edu.

Editor: D. L. Burns

{dagger} Present address: Advanced Center for Genome Technology/Department of Botany and Microbiology, University of Oklahoma, Norman, OK 73069-0245.

Infection and Immunity, May 2003, p. 2920-2923, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2920-2923.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Baldwin, D. N., Shepherd, B., Kraemer, P., Hall, M. K., Sycuro, L. K., Pinto-Santini, D. M., Salama, N. R. (2007). Identification of Helicobacter pylori Genes That Contribute to Stomach Colonization. Infect. Immun. 75: 1005-1016 [Abstract] [Full Text]  
  • Thiele, I., Vo, T. D., Price, N. D., Palsson, B. O. (2005). Expanded Metabolic Reconstruction of Helicobacter pylori (iIT341 GSM/GPR): an In Silico Genome-Scale Characterization of Single- and Double-Deletion Mutants. J. Bacteriol. 187: 5818-5830 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»