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Infection and Immunity, May 2003, p. 2920-2923, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2920-2923.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The Entner-Doudoroff Pathway Has Little Effect on Helicobacter pylori Colonization of Mice

Amy E. Wanken,1 Tyrrell Conway,2,{dagger} and Kathryn A. Eaton1*

Department of Veterinary Biosciences,1 Department of Microbiology, Ohio State University, Columbus, Ohio 432102

Received 11 December 2002/ Returned for modification 9 January 2003/ Accepted 6 February 2003

Helicobacter pylori mutants deficient in 6-phosphogluconate dehydratase (6PGD) were constructed. Colonization densities were lower and minimum infectious doses were higher for mutant strains than for wild-type strains. In spite of better colonization, however, wild-type strains did not displace the mutant in cocolonization experiments. Loss of 6PGD diminishes the fitness of H. pylori in vivo, but the pathway is nonessential for colonization.

* Corresponding author. Mailing address: Department of Veterinary Biosciences, Ohio State University, Goss Laboratory, 1925 Coffey Rd., Columbus, OH 43210. Phone: (614) 292-9667. Fax: (614) 292-6473. E-mail: eaton.1{at}osu.edu.

Editor: D. L. Burns

{dagger} Present address: Advanced Center for Genome Technology/Department of Botany and Microbiology, University of Oklahoma, Norman, OK 73069-0245.

Infection and Immunity, May 2003, p. 2920-2923, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2920-2923.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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