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Infection and Immunity, May 2003, p. 2938-2940, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2938-2940.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Humoral Immunity Reflects Altered T Helper Cell Bias in Borrelia burgdorferi-Infected {gamma}{delta} T-Cell-Deficient Mice

Linda K. Bockenstedt,1* Marie-Claude Shanafelt,1 Alexia Belperron,1 Jialing Mao,1 and Stephen W. Barthold2

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520,1 Center for Comparative Medicine, University of California, Davis, California 956162

Received 26 November 2002/ Returned for modification 30 December 2002/ Accepted 14 January 2003

In murine Lyme borreliosis, the absence of {gamma}{delta} T lymphocytes augments the T helper cell 2 type humoral response but does not alter disease susceptibility. Arthropod transmission of Borrelia burgdorferi spirochetes results in similar antibody isotypes when {gamma}{delta} T cells are present, suggesting that vector effects can negate {gamma}{delta} T-cell functions in vivo.

* Corresponding author. Mailing address: 609 LCI, Section of Rheumatology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06520-8031. Phone: (203) 785-7063. Fax: (203) 785-7053. E-mail: linda.bockenstedt{at}yale.edu.

Editor: F. C. Fang

Infection and Immunity, May 2003, p. 2938-2940, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2938-2940.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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