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Infection and Immunity, May 2003, p. 2945-2949, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2945-2949.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

V{gamma}9V{delta}2 T-Cell Anergy and Complementarity-Determining Region 3-Specific Depletion during Paroxysm of Nonendemic Malaria Infection

Federico Martini,1* Maria Grazia Paglia,1 Carla Montesano,1 Patrick J. Enders,2 Marco Gentile,3 C. David Pauza,2 Cristiana Gioia,1 Vittorio Colizzi,4 Pasquale Narciso,3 Leopoldo Paolo Pucillo,1 and Fabrizio Poccia1

Laboratory of Clinical Pathology,1 4th Clinical Division,3 ICAERI, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy,4 Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 210212

Received 9 September 2002/ Returned for modification 5 November 2002/ Accepted 20 January 2003

V{gamma}9V{delta}2 T lymphocytes strongly respond to phosphoantigens from Plasmodium parasites. Thus, we analyzed the changes in V{gamma}9V{delta}2 T-cell function and repertoire during the paroxysm phase of nonendemic malaria infection. During malaria paroxysm, V{gamma}9V{delta}2 T cells were early activated but rapidly became anergic and finally loose J{gamma}1.2 V{gamma}9 complementarity-determining region 3 transcripts.

* Corresponding author. Mailing address: National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Via Portuense 292, 00149 Rome, Italy. Phone: 39 06 55170 907. Fax: 39 06 55170 904. E-mail: martini{at}inmi.it.

Editor: S. H. E. Kaufmann

Infection and Immunity, May 2003, p. 2945-2949, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2945-2949.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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