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Infection and Immunity, May 2003, p. 2950-2955, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2950-2955.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Coordinated Expression of Tracheal Antimicrobial Peptide and Inflammatory-Response Elements in the Lungs of Neonatal Calves with Acute Bacterial Pneumonia

Jessica M. Caverly,1 Gill Diamond,2 Jack M. Gallup,1 Kim A. Brogden,3 Richard A. Dixon,4 and Mark R. Ackermann1*

Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011-1250,1 University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103-2714,2 Respiratory Diseases of Livestock Research Unit, USDA Agricultural Research Service, National Animal Disease Center, Ames, Iowa 50010,3 Texas Biotechnology Corporation, Houston, Texas 770304

Received 4 November 2002/ Returned for modification 18 December 2002/ Accepted 10 February 2003

Lung tissue removed from neonatal calves with acute Mannheimia haemolytica pneumonia showed that rapid up-regulation of the basal mRNA expression of tracheal antimicrobial peptide (TAP), NF-{kappa}B, and intercellular adhesion molecule 1 occurred after infection; TAP and interleukin 8 expression were highly correlated. This work suggests that the coordinated expression of ß-defensin and inflammatory elements occurs during bacterial pneumonia.

* Corresponding author. Mailing address: Department of Veterinary Pathology, 2738 Veterinary Medicine, Iowa State University, Ames, IA 50011-1250. Phone: (515) 294-3647. Fax: (515) 294-5423. E-mail: mackerma{at}iastate.edu.

Editor: F. C. Fang

Infection and Immunity, May 2003, p. 2950-2955, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2950-2955.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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