This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jakobsen, H.
Right arrow Articles by Jonsdottir, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jakobsen, H.
Right arrow Articles by Jonsdottir, I.

 Previous Article  |  Next Article 

Infection and Immunity, May 2003, p. 2956-2959, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2956-2959.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Pneumococcal Serotype 19F Conjugate Vaccine Induces Cross-Protective Immunity to Serotype 19A in a Murine Pneumococcal Pneumonia Model

Håvard Jakobsen,1 Viktor D. Sigurdsson,1 Sigurveig Sigurdardottir,1 Dominique Schulz,2 and Ingileif Jonsdottir1,3*

Department of Immunology, Landspitali—University Hospital, and Medical Faculty, University of Iceland, Reykjavik, Iceland,1 Aventis Pasteur, Marcy l'Etoile, France2

Received 14 November 2002/ Returned for modification 19 December 2002/ Accepted 6 February 2003

Immunization with a pneumococcal conjugate vaccine (PNC) containing serotype 19F induces cross-reactive antibodies to 19A in mice and human infants. Active immunization with PNC and passive immunization with serum samples from infants vaccinated with PNC containing serotype 19F, but not serotype 19A, protected against lung infection caused by both serotypes in a murine model.

* Corresponding author. Mailing address: Department of Immunology, Landspitali—University Hospital, Hringbraut, 101 Reykjavik, Iceland. Phone: 354-543 5812. Fax: 354-543 4828. E-mail: ingileif{at}landspitali.is.

Editor: J. N. Weiser

Infection and Immunity, May 2003, p. 2956-2959, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2956-2959.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Lee, H., Nahm, M. H., Burton, R., Kim, K.-H. (2009). Immune Response in Infants to the Heptavalent Pneumococcal Conjugate Vaccine against Vaccine-Related Serotypes 6A and 19A. CVI 16: 376-381 [Abstract] [Full Text]  
  • Richter, M. Y., Jakobsen, H., Haeuw, J.-F., Power, U. F., Jonsdottir, I. (2005). Protective Levels of Polysaccharide-Specific Maternal Antibodies May Enhance the Immune Response Elicited by Pneumococcal Conjugates in Neonatal and Infant Mice. Infect. Immun. 73: 956-964 [Abstract] [Full Text]  
  • Richter, M. Y., Jakobsen, H., Birgisdottir, A., Haeuw, J.-F., Power, U. F., Del Giudice, G., Bartoloni, A., Jonsdottir, I. (2004). Immunization of Female Mice with Glycoconjugates Protects Their Offspring against Encapsulated Bacteria. Infect. Immun. 72: 187-195 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»