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Infection and Immunity, May 2003, p. 2970-2975, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2970-2975.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Structural and Functional Cellular Changes Induced by Burkholderia pseudomallei Rhamnolipid

Institute of Medical Microbiology,¹ Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover,³ German Research Centre for Biotechnology, Braunschweig, Germany²

Received 26 June 2002/ Returned for modification 17 October 2002/ Accepted 13 January 2003

In this study we report that extracellular Burkholderia pseudomallei rhamnolipid induced cytopathic changes characterized by retraction, rounding up, and, finally, detachment in phagocytic and nonphagocytic cell lines. These changes were due to a progressive reorganization of the F-actin network resulting in impaired cell cycle progression and a reduced phagocytic function of macrophages.

Editor: B. B. Finlay

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