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Infection and Immunity, June 2003, p. 3357-3360, Vol. 71, No. 6
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.6.3357-3360.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Helicobacter pylori Infection Induces Interleukin-8 Receptor Expression in the Human Gastric Epithelium

Fredrik Bäckhed,1* Elisabeth Torstensson,1 Delphine Seguin,2 Agneta Richter-Dahlfors,1 and Bachra Rokbi2

Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden,1 Aventis Pasteur, Marcy L'Etoile, France2

Received 23 December 2002/ Returned for modification 14 February 2003/ Accepted 24 February 2003

The gastric pathogen Helicobacter pylori is known to activate multiple proinflammatory signaling pathways in epithelial cells. In this study, we addressed the question of whether expression of the interleukin-8 receptors IL-8RA (CXCR1) and IL-8RB (CXCR2) is upregulated in H. pylori-infected human gastric biopsy samples. Biopsy samples from patients infected with H. pylori strains harboring the cag pathogenicity island (PAI) expressed larger amounts of both receptors. In addition, IL-8RB expression was induced in the gastric epithelial cell line AGS upon infection with a clinical isolate containing the cag PAI, while a strain lacking the cag PAI did not. Our finding suggests that gastric epithelial cells express IL-8R in response to H. pylori infection.

* Corresponding author. Present address: Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S. Euclid Ave., Box 8103, St. Louis, MO 63110. Phone: (314) 362-5443. Fax: (314) 362-7058. E-mail: fbackhed{at}pcg.wustl.edu.

Editor: J. D. Clements

Infection and Immunity, June 2003, p. 3357-3360, Vol. 71, No. 6
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.6.3357-3360.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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