This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shomer, N. H.
Right arrow Articles by Ruddle, N. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shomer, N. H.
Right arrow Articles by Ruddle, N. H.

 Previous Article  |  Next Article 

Infection and Immunity, June 2003, p. 3572-3577, Vol. 71, No. 6
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.6.3572-3577.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Helicobacter-Induced Chronic Active Lymphoid Aggregates Have Characteristics of Tertiary Lymphoid Tissue

Nirah H. Shomer,1,{dagger}* James G. Fox,2 Amy E. Juedes,3,{ddagger} and Nancy H. Ruddle3

Section of Comparative Medicine, Yale University, New Haven, Connecticut 06510,1 Massachusetts Institute of Technology, Division of Comparative Medicine, Cambridge, Massachusetts 02139,2 Department of Epidemiology and Public Health and Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-80343

Received 10 December 2002/ Returned for modification 10 February 2003/ Accepted 19 March 2003

Susceptible strains of mice that are naturally or experimentally infected with murine intestinal helicobacter species develop hepatic inflammatory lesions that have previously been described as chronic active hepatitis. The inflammatory infiltrates in some models of chronic autoimmunity or inflammation resemble tertiary lymphoid organs hypothesized to arise by a process termed lymphoid organ neogenesis. To determine whether hepatic inflammation caused by infection with helicobacter could give rise to tertiary lymphoid organs, we used fluorescence-activated cell sorting, immunohistochemistry, and in situ hybridization techniques to identify specific components characteristic of lymphoid organs in liver tissue sections and liver cell suspensions from helicobacter-infected mice. Small venules (high endothelial venules [HEVs]) in inflammatory lesions in Helicobacter species-infected livers were positive for peripheral node addressin. Mucosal addressin cell adhesion molecule also stained HEVs and cells with a staining pattern consistent with scattered stromal cells. The chemokines SLC (CCL 21) and BLC (CXCL13) were present, as were B220-positive B cells and T cells. The latter included a naïve (CD45lo-CD62Lhi) population. These findings suggest that helicobacter-induced chronic active hepatitis arises through the process of lymphoid organ neogenesis.

* Corresponding author. Mailing address: Laboratory Animal Science Center, 715 Albany St., W707, Boston, MA 02118. Phone: (617) 638-4090. Fax: (617) 638-4055. E-mail: nirah{at}bu.edu.

Editor: B. B. Finlay

{dagger} Present address: Boston University, Laboratory Animal Science Center, Boston, MA 02118.

{ddagger} Present address: LaJolla Institute of Allergy and Immunology, San Diego, CA 92121.

Infection and Immunity, June 2003, p. 3572-3577, Vol. 71, No. 6
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.6.3572-3577.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Bende, R. J., van Maldegem, F., van Noesel, C. J.M. (2009). Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas. haematol 94: 1109-1123 [Abstract] [Full Text]  
  • Kendall, P. L., Yu, G., Woodward, E. J., Thomas, J. W. (2007). Tertiary Lymphoid Structures in the Pancreas Promote Selection of B Lymphocytes in Autoimmune Diabetes. J. Immunol. 178: 5643-5651 [Abstract] [Full Text]  
  • Thaunat, O., Field, A.-C., Dai, J., Louedec, L., Patey, N., Bloch, M.-F., Mandet, C., Belair, M.-F., Bruneval, P., Meilhac, O., Bellon, B., Joly, E., Michel, J.-B., Nicoletti, A. (2005). Lymphoid neogenesis in chronic rejection: Evidence for a local humoral alloimmune response. Proc. Natl. Acad. Sci. USA 102: 14723-14728 [Abstract] [Full Text]  
  • Rogers, A. B., Boutin, S. R., Whary, M. T., Sundina, N., Zhongming Ge, , Cormier, K., Fox, J. G. (2004). Progression of Chronic Hepatitis and Preneoplasia in Helicobacter hepaticus-Infected A/JCr Mice. Toxicol Pathol 32: 668-677 [Abstract]  
  • Tesar, B. M., Chalasani, G., Smith-Diggs, L., Baddoura, F. K., Lakkis, F. G., Goldstein, D. R. (2004). Direct Antigen Presentation by a Xenograft Induces Immunity Independently of Secondary Lymphoid Organs. J. Immunol. 173: 4377-4386 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»