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Infection and Immunity, June 2003, p. 3603-3606, Vol. 71, No. 6
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.6.3603-3606.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

A Dominant Role for Extracellular Glutathione S-Transferase from Onchocerca volvulus Is the Production of Prostaglandin D₂

Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg,¹ Department of Food Chemistry, University of Hamburg, 20146 Hamburg, Germany²

Received 22 October 2002/ Returned for modification 27 January 2003/ Accepted 7 March 2003

The extracellular glutathione S-transferase from the filarial parasite Onchocerca volvulus (Ov-GST1) is a glutathione-dependent prostaglandin D synthase. Ov-GST1, located in the outer hypodermal lamellae and in parts of the cuticle, produces prostaglandin D₂ directly at the parasite-host interface. Ov-GST1 therefore has the potential to participate in the modulation of the host immune response by contributing to the production of prostanoids; this supports the predominant hypothesis that parasite-derived eicosanoids influence host inflammatory and immune cells.

Editor: S. H. E. Kaufmann

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