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Infection and Immunity, June 2003, p. 3628-3633, Vol. 71, No. 6
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.6.3628-3633.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Vaccine-Induced Protection against Helicobacter pylori in Mice Lacking Both Antibodies and Interleukin-4

Department of Pathology,¹ Center for Global Health and Diseases,² Department of Pediatrics, Case Western Reserve University,⁴ Medical Research Services, Veterans Affairs Medical Center, Cleveland, Ohio 44106³

Received 6 November 2002/ Returned for modification 30 December 2002/ Accepted 10 March 2003

To test the hypothesis that a Th2 response to Helicobacter pylori is necessary for protection and to address the possibility that humoral and Th2 cellular responses may compensate for each other, we generated mice deficient in both interleukin-4 (IL-4) and antibodies. The immunized double-knockout mice were protected from H. pylori challenge, as were the parental strains and wild-type C57BL/6 mice. Neutralization of IL-4 in B-cell-deficient mice did not prevent protection. Immunized IL-5-deficient mice were also protected. Thus, IL-4 and IL-5 are not essential for protection.

Editor: F. C. Fang

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