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Infection and Immunity, June 2003, p. 3639-3644, Vol. 71, No. 6
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.6.3639-3644.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Complete Sequence of the cap Locus of Haemophilus influenzae Serotype b and Nonencapsulated b Capsule-Negative Variants

Atlanta Veterans Affairs Medical Center and Department of Medicine, Emory University School of Medicine, Decatur, Georgia 30033

Received 3 December 2002/ Returned for modification 6 February 2003/ Accepted 13 March 2003

The complete capsule (cap) loci from three Haemophilus influenzae strains, one serotype b (Hib) and two nonencapsulated b capsule-negative variants, were sequenced. Two new open reading frames, hcsA and hcsB, were identified in region III and thought to be involved in postpolymerization modification of the capsule. The location of the cap locus in the Haemophilus influenzae chromosome was identified within section 97 of the Rd genome (chromosomal coordinates 1074542 to 1086327) and found to be the same for the Hib and two Hib^- strains as well as some other encapsulated division I H. influenzae strains.

Editor: J. N. Weiser

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