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Infection and Immunity, July 2003, p. 4159-4162, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4159-4162.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Yersinia pestis TonB: Role in Iron, Heme, and Hemoprotein Utilization

Robert D. Perry,* Jessica Shah, Scott W. Bearden,{dagger} Jan M. Thompson, and Jacqueline D. Fetherston

Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky

Received 13 January 2003/ Returned for modification 11 March 2003/ Accepted 16 April 2003

In Yersinia pestis, the siderophore-dependent yersiniabactin (Ybt) iron transport system and heme transport system (Hmu) have putative TonB-dependent outer membrane receptors. Here we demonstrate that hemin uptake and iron utilization from Ybt are TonB dependent. However, the Yfe iron and manganese transport system does not require TonB.

* Corresponding author. Mailing address: Department of Microbiology, Immunology, and Molecular Genetics, MS415 Medical Center, University of Kentucky, Lexington, KY 40536-0298. Phone: (859) 323-6341. Fax: (859) 257-8994. E-mail: rperry{at}pop.uky.edu.

Editor: J. T. Barbieri

{dagger} Present address: Centers for Disease Control, Division of Vector-Borne Infectious Diseases, Bacterial Zoonoses Branch, Fort Collins, Colo.

Infection and Immunity, July 2003, p. 4159-4162, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4159-4162.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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