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Infection and Immunity, July 2003, p. 4182-4185, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4182-4185.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Leptin Modulates Neutrophil Phagocytosis of Klebsiella pneumoniae

Sharlene I. Moore,1 Gary B. Huffnagle,2 Gwo-Hsiao Chen,2 Eric S. White,2 and Peter Mancuso3*

Program in Human Nutrition,1 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine,2 Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 481093

Received 7 January 2003/ Returned for modification 28 January 2003/ Accepted 2 April 2003

Leptin is a pleiotropic hormone-cytokine known to regulate energy homeostasis and immune function. Neutrophils from leptin-deficient mice exhibited impaired phagocytosis of Klebsiella pneumoniae opsonized with serum containing complement and reduced CD11b expression that could be restored with exogenous leptin. These results suggest that leptin is required for normal neutrophil complement-mediated phagocytosis of bacteria.

* Corresponding author. Mailing address: Department of Environmental Health Sciences, University of Michigan, 1420 Washington Heights, SPHII, Ann Arbor, MI 48109-2029. Phone: (734) 615-5158. Fax: (734) 763-8095. E-mail: pmancuso{at}umich.edu.

Editor: J. N. Weiser

Infection and Immunity, July 2003, p. 4182-4185, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4182-4185.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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