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Infection and Immunity, July 2003, p. 4186-4189, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4186-4189.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Antigen Processing of the Heptavalent Pneumococcal Conjugate Vaccine Carrier Protein CRM197 Differs Depending on the Serotype of the Attached Polysaccharide

Ethan G. Leonard,1 David H. Canaday,2 Clifford V. Harding,3 and John R. Schreiber1,3*

Departments of Pediatrics,1 Medicine,2 Pathology, Case Western Reserve University, and the Division of Infectious Diseases/Allergy/Immunology/Rheumatology, Rainbow Babies and Children's Hospital, Cleveland, Ohio 441063

Received 19 February 2003/ Returned for modification 3 April 2003/ Accepted 26 April 2003

The pneumococcal (Pn) conjugate vaccine includes seven different polysaccharides (PS) conjugated to CRM197. Utilizing antigen-processing cells and a CRM197-specific mouse T-cell hybridoma, we found that the serotype of conjugated PnPS dramatically affected antigen processing of CRM197. Unconjugated CRM197 and serotype conjugates 14 and 18C were processed more efficiently.

* Corresponding author. Mailing address: Division of Infectious Diseases/Allergy/Immunology/Rheumatology, Rainbow Babies and Children's Hospital, 11100 Euclid Ave., Cleveland, OH 44106. Phone: (216) 844-3645. Fax: (216) 844-8362. E-mail: jrs3{at}po.cwru.edu.

Editor: J. D. Clements

Infection and Immunity, July 2003, p. 4186-4189, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4186-4189.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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