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Infection and Immunity, August 2003, p. 4795-4803, Vol. 71, No. 8
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.8.4795-4803.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Secreted Effector Proteins of Salmonella enterica Serotype Typhimurium Elicit Host-Specific Chemokine Profiles in Animal Models of Typhoid Fever and Enterocolitis

Shuping Zhang,1,{dagger} L. Garry Adams,1 Jairo Nunes,1 Sangeeta Khare,1 Renée M. Tsolis,2 and Andreas J. Bäumler2*

Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4467,1 Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University System Health Science Center, College Station, Texas 77843-11142

Received 7 March 2003/ Returned for modification 28 March 2003/ Accepted 5 May 2003

Infection of bovine ligated loops with the Salmonella enterica serotype Typhimurium wild type but not a sipA sopABDE2 mutant resulted in fluid accumulation, polymorphonuclear cell infiltration, and expression of CXC chemokines, particularly GRO{alpha}. None of these sipA sopABDE2-dependent responses was observed in murine-ligated loops. The majority of GRO{alpha} transcripts localized to bovine intestinal epithelium. Thus, different disease outcomes between mice (i.e., no diarrhea) and calves (i.e., diarrhea) may be due to differences in sipA sopABDE2-dependent CXC chemokine gene expression in epithelial cells.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University System Health Science Center, 407 Reynolds Medical Building, 1114 TAMU, College Station, TX 77843-1114. Phone: (979) 862-7756. Fax: (979) 845-3479. E-mail: abaumler{at}tamu.edu.

Editor: F. C. Fang

{dagger} Present address: Mississippi Veterinary Diagnostic and Research Laboratory, Department of Veterinary Pathobiology/Population Medicine, College of Veterinary Medicine, Mississippi State University, Jackson, MS 39296.

Infection and Immunity, August 2003, p. 4795-4803, Vol. 71, No. 8
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.8.4795-4803.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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